HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(2,6-Dimethylpyridin-3-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 3-Bromo-2,6-dimethylpyridine | HCID 603971 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2,6-Dimethylpyridin-3-yl)piperazine | HCID 58484703 | 97.9% |
Reaction Steps
By reaction and treatment in the same manner as in Preparation Example 88 and using 1-Boc-piperazine (2.0 g) and 3-bromo-2,6-dimethylpyridine (2.0 g), a compound was obtained. To the compound were added water and potassium carbonate, and the mixture was extracted with ethyl acetate. The solvent was evaporated to give the title compound (2.01 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-a5150235af7e4976b4749cd0d1663f14 |
| Source note | uspto-grants-2013_01 |