Potassium Carbonate → 1-(2,6-Dimethylpyridin-3-yl)piperazine

HRID 1804107Notes

Reaction equation

HRID 1804107 reaction equation
[C:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)(OC(C)(C)C)=O.Br[C:15]1[C:16]([CH3:22])=[N:17][C:18](C)=[CH:19][CH:20]=1.C(=O)([O-])[O-].[K+].[K+]>O>[CH3:19][C:18]1[C:1]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[CH:20][CH:15]=[C:16]([CH3:22])[N:17]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 6039713-Bromo-2,6-dimethylpyridine

Product 1

HCID 584847031-(2,6-Dimethylpyridin-3-yl)piperazineYield 97.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

By reaction and treatment in the same manner as in Preparation Example 88 and using 1-Boc-piperazine (2.0 g) and 3-bromo-2,6-dimethylpyridine (2.0 g), a compound was obtained. To the compound were added water and potassium carbonate, and the mixture was extracted with ethyl acetate. The solvent was evaporated to give the title compound (2.01 g).

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 88
  3. customa compound was obtained
  4. extractionthe mixture was extracted with ethyl acetate
  5. customThe solvent was evaporated

Sources & evidence

ORD record
ord-a5150235af7e4976b4749cd0d1663f14
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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