Iodoethane → HCID 54755238, compound

HRID 1804111Notes

Reaction equation

HRID 1804111 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:30])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][OH:27])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][C:16]=2[F:29])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:31](I)[CH3:32]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:30])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][O:27][CH2:31][CH3:32])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][C:16]=2[F:29])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 54755236HCID 54755236, compound

Product 1

HCID 54755238HCID 54755238, compoundYield 71.2%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-4-[2-fluoro-4-(4-hydroxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester (2.20 g) described in Preparation Example 156 and ethyl iodide (972 mg), the title compound (1.67 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-775ca54156914400be0ff395f70702a0
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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