(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester

HRID 1804113노트

반응식

HRID 1804113 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18](I)=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:23]=[C:24]1[NH:28][C@H:27]([CH2:29][O:30][C:31](=[O:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:26][O:25]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][C:18]([N:28]3[C@H:27]([CH2:29][O:30][C:31](=[O:38])[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH2:26][O:25][C:24]3=[O:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 16213752(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 44157877Tert-butyl 4-(4-iodobenzoyl)piperazine-1-carboxylate

생성물 1

HCID 58484870(R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester수율 90.3%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 91 and using 4-(4-iodobenzoyl)piperazine-1-carboxylic acid tert-butyl ester (3.75 g) described in Preparation Example 161 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (1.99 g), the title compound (4.14 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 91

출처 및 근거

ORD 기록
ord-d18b7af3194d468da2611bf617e3e22c
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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