Iodoethane → HCID 58484859, compound

HRID 1804115Notes

Reaction equation

HRID 1804115 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:29])[C:15]2[CH:20]=[CH:19][C:18]([N:21]3[C@H:25]([CH2:26][OH:27])[CH2:24][O:23][C:22]3=[O:28])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:30](I)[CH3:31]>>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([C:14](=[O:29])[C:15]2[CH:16]=[CH:17][C:18]([N:21]3[C@H:25]([CH2:26][O:27][CH2:30][CH3:31])[CH2:24][O:23][C:22]3=[O:28])=[CH:19][CH:20]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 58484613HCID 58484613, compound

Product 1

HCID 58484859HCID 58484859, compoundYield 75.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-4-[4-(4-hydroxymethyl-2-oxooxazolidin-3-yl)benzoyl]piperazine-1-carboxylic acid tert-butyl ester (2.43 g) described in Preparation Example 163 and ethyl iodide (1.12 g), the title compound (1.97 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-0e3d825b4e0548ecb7216594a1151a9e
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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