HRID1804117

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16213752

未命名化合物

结构：CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(Br)cc2S(C)(=O)=O)CC1

HCID58484680

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CCN(C(=O)c2ccc(N3C(=O)OC[C@H]3COC(=O)c3ccccc3)cc2S(C)(=O)=O)CC1

HCID58484795

未命名化合物

收率 79.5%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Preparation Example 91 and using 4-(4-bromo-2-methanesulfonylbenzoyl)piperazine-1-carboxylic acid tert-butyl ester (2.24 g) described in Preparation Example 168 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (1.11 g), the title compound (2.34 g) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner
customas in Preparation Example 91

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7a1715b6a88b4517b5385854051af1fd
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354401B2
来源说明: uspto-grants-2013_01

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]2[CH:20]=[CH:19][C:18](Br)=[CH:17][C:16]=2[S:22]([CH3:25])(=[O:24])=[O:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:27]=[C:28]1[NH:32][C@H:31]([CH2:33][O:34][C:35](=[O:42])[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:30][O:29]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]2[CH:20]=[CH:19][C:18]([N:32]3[C@H:31]([CH2:33][O:34][C:35](=[O:42])[C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[CH2:30][O:29][C:28]3=[O:27])=[CH:17][C:16]=2[S:22]([CH3:25])(=[O:24])=[O:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]