(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)-2-methanesulfonylbenzoyl]piperazine-1-carboxylic acid tert-butyl ester

HRID 1804117노트

반응식

HRID 1804117 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]2[CH:20]=[CH:19][C:18](Br)=[CH:17][C:16]=2[S:22]([CH3:25])(=[O:24])=[O:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[O:27]=[C:28]1[NH:32][C@H:31]([CH2:33][O:34][C:35](=[O:42])[C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:30][O:29]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:26])[C:15]2[CH:20]=[CH:19][C:18]([N:32]3[C@H:31]([CH2:33][O:34][C:35](=[O:42])[C:36]4[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=4)[CH2:30][O:29][C:28]3=[O:27])=[CH:17][C:16]=2[S:22]([CH3:25])(=[O:24])=[O:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 16213752(4S)-4-(Benzoyloxymethyl)oxazolidine-2-oneHCID 584846804-(4-Bromo-2-methanesulfonylbenzoyl)piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 58484795(R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)-2-methanesulfonylbenzoyl]piperazine-1-carboxylic acid tert-butyl ester수율 79.5%

실험 절차

By reaction and treatment in the same manner as in Preparation Example 91 and using 4-(4-bromo-2-methanesulfonylbenzoyl)piperazine-1-carboxylic acid tert-butyl ester (2.24 g) described in Preparation Example 168 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (1.11 g), the title compound (2.34 g) was obtained.

후처리

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 91

출처 및 근거

ORD 기록
ord-7a1715b6a88b4517b5385854051af1fd
출처 데이터셋
uspto-grants-2013_01
특허 번호
US08354401B2

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