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(4S)-4-(Benzoyloxymethyl)oxazolidine-2-one → (R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)-2-methanesulfonylbenzoyl]piperazine-1-carboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (4S)-4-(Benzoyloxymethyl)oxazolidine-2-one | HCID 16213752 | — |
| 反応物 | 4-(4-Bromo-2-methanesulfonylbenzoyl)piperazine-1-carboxylic acid tert-butyl ester | HCID 58484680 | — |
| 生成物 | (R)-4-[4-(4-benzoyloxymethyl-2-oxooxazolidin-3-yl)-2-methanesulfonylbenzoyl]piperazine-1-carboxylic acid tert-butyl ester | HCID 58484795 | 79.5% |
反応手順
By reaction and treatment in the same manner as in Preparation Example 91 and using 4-(4-bromo-2-methanesulfonylbenzoyl)piperazine-1-carboxylic acid tert-butyl ester (2.24 g) described in Preparation Example 168 and benzoic acid (R)-2-oxooxazolidin-4-ylmethyl ester (1.11 g), the title compound (2.34 g) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08354401B2 |
| 出典データセット | uspto-grants-2013_01 |
| ORD ID | ord-7a1715b6a88b4517b5385854051af1fd |
| 出典メモ | uspto-grants-2013_01 |