4-Iodobenzoyl chloride → (4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 1804121Notes

Reaction equation

HRID 1804121 reaction equation
[CH3:1][C:2]1[C:3]([N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[N:4][C:5]([CH3:9])=[C:6]([CH3:8])[CH:7]=1.[I:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[I:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([N:13]2[CH2:12][CH2:11][N:10]([C:3]3[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[C:5]([CH3:9])[N:4]=3)[CH2:15][CH2:14]2)=[O:22])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 743734-Iodobenzoyl chlorideHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

Product 1

HCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanoneYield 94.8%

Procedure

By reaction and treatment in the same manner as in Preparation Example 161 and using 1-(3,5,6-trimethylpyridin-2-yl)piperazine (4.39 g) described in Preparation Example 175 and 4-iodobenzoyl chloride (5.98 g), the title compound (8.82 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 161

Sources & evidence

ORD record
ord-ea27837bcef04a7ebadc21c36b46c8a2
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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