2-Oxazolidinone → 3-{2-Chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804143Notes

Reaction equation

HRID 1804143 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[Cl:24].[O:25]1[CH2:29][CH2:28][NH:27][C:26]1=[O:30]>>[Cl:24][C:3]1[CH:4]=[C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:7][C:2]=1[N:27]1[CH2:28][CH2:29][O:25][C:26]1=[O:30]

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484864(4-Bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 461899453-{2-Chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 57.8%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-3-chlorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (815 mg) described in Preparation Example 3 and oxazolidin-2-one (174 mg), the title compound (478 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-b8dd6a2f786642e28d49a5febb35bd33
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…