2-Oxazolidinone → 3-{5-Chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-2-fluorophenyl}oxazolidin-2-one

HRID 1804147Notes

Reaction equation

HRID 1804147 reaction equation
Br[C:2]1[C:7]([F:8])=[CH:6][C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH3:24])[CH2:13][CH2:12]2)=[O:10])=[C:4]([Cl:25])[CH:3]=1.[O:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[Cl:25][C:4]1[C:5]([C:9]([N:11]2[CH2:16][CH2:15][N:14]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][C:18]=3[CH3:24])[CH2:13][CH2:12]2)=[O:10])=[CH:6][C:7]([F:8])=[C:2]([N:28]2[CH2:29][CH2:30][O:26][C:27]2=[O:31])[CH:3]=1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484863(4-Bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

Product 1

HCID 673823373-{5-Chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-2-fluorophenyl}oxazolidin-2-oneYield 58.6%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (851 mg) described in Preparation Example 7 and oxazolidin-2-one (174 mg), the title compound (506 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-4cdefc02fe2f4a90976e94920352648b
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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