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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804147Generated: October 30, 2026

2-Oxazolidinone → 3-{5-Chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-2-fluorophenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804147

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-OxazolidinoneHCID 73949—
Reactant(4-Bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanoneHCID 58484863—
Product3-{5-Chloro-4-[4-(2,4-dimethylphenyl)piperazine-1-carbonyl]-2-fluorophenyl}oxazolidin-2-oneHCID 6738233758.6%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-chloro-5-fluorophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (851 mg) described in Preparation Example 7 and oxazolidin-2-one (174 mg), the title compound (506 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-4cdefc02fe2f4a90976e94920352648b
Source noteuspto-grants-2013_01