2-Oxazolidinone → 3-{4-[4-(2-Ethyl-4-methylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-one

HRID 1804165Notes

Reaction equation

HRID 1804165 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH2:23][CH3:24])[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:3]=1.[O:29]1[CH2:33][CH2:32][NH:31][C:30]1=[O:34]>>[CH2:23]([C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([N:31]3[CH2:32][CH2:33][O:29][C:30]3=[O:34])=[CH:3][C:4]=2[S:25]([CH3:28])(=[O:27])=[O:26])=[O:9])[CH2:11][CH2:12]1)[CH3:24]

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484563(4-Bromo-2-methanesulfonylphenyl)[4-(2-ethyl-4-methylphenyl)piperazin-1-yl]methanone

Product 1

HCID 673809753-{4-[4-(2-Ethyl-4-methylphenyl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}oxazolidin-2-oneYield 1.2%

Procedure

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(2-ethyl-4-methylphenyl)piperazin-1-yl]methanone (1.8 g) described in Preparation Example 15 and oxazolidin-2-one (418 mg), the title compound (22 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-870dae39a10447789cbea9d4a890ce11
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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