2-Oxazolidinone → 3-{4-[4-(2-Cyclopropyl-4-methylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804166Notes

Reaction equation

HRID 1804166 reaction equation
[CH:1]1([C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:24]=[CH:23][C:22](I)=[CH:21][CH:20]=3)=[O:18])[CH2:13][CH2:12]2)[CH2:3][CH2:2]1.[O:26]1[CH2:30][CH2:29][NH:28][C:27]1=[O:31]>>[CH:1]1([C:4]2[CH:9]=[C:8]([CH3:10])[CH:7]=[CH:6][C:5]=2[N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[CH:24]=[CH:23][C:22]([N:28]4[CH2:29][CH2:30][O:26][C:27]4=[O:31])=[CH:21][CH:20]=3)=[O:18])[CH2:13][CH2:12]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 739492-OxazolidinoneHCID 58484789[4-(2-Cyclopropyl-4-methylphenyl)piperazin-1-yl](4-iodophenyl)methanone

Product 1

HCID 461901753-{4-[4-(2-Cyclopropyl-4-methylphenyl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 27.1%

Procedure

By reaction and treatment in the same manner as in Example 1 and using [4-(2-cyclopropyl-4-methylphenyl)piperazin-1-yl](4-iodophenyl)methanone (280 mg) described in Preparation Example 17 and oxazolidin-2-one (313 mg), the title compound (69 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 1

Sources & evidence

ORD record
ord-ff6acbb897ce4558ab5d1d19fcf66a52
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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