HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,4-Dimethylbenzoyl)piperidine hydrochloride → (R)-3-{4-[4-(2,4-dimethylbenzoyl)piperidine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,4-Dimethylbenzoyl)piperidine hydrochloride | HCID 43810626 | — |
| Reactant | (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid | HCID 58484719 | — |
| Product | (R)-3-{4-[4-(2,4-dimethylbenzoyl)piperidine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one | HCID 67380785 | 104.5% |
Reaction Steps
By reaction and treatment in the same manner as in Example 49 and using (2,4-dimethylphenyl)piperidin-4-ylmethanone hydrochloride (253 mg) and (R)-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (211 mg) described in Preparation Example 37, the title compound (419 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-0430489baa074dee8a1afe9c31b31131 |
| Source note | uspto-grants-2013_01 |