HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-4-isopropyl-3-{4-[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid | HCID 58484694 | — |
| Reactant | 1-(3-Methyl-5-trifluoromethylpyridin-2-yl)piperazine | HCID 58484729 | — |
| Product | (R)-4-isopropyl-3-{4-[4-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one | HCID 67380990 | 30.7% |
Reaction Steps
By reaction and treatment in the same manner as in Example 29 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (499 mg) described in Preparation Example 18 and 1-(3-methyl-5-trifluoromethylpyridin-2-yl)piperazine (490 mg) described in Preparation Example 51, the title compound (292 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-777b159fbf0b40bb9066bac907350dc0 |
| Source note | uspto-grants-2013_01 |