1-(5-Methyl-2-pyridinyl)piperazine → (R)-4-isopropyl-3-{4-[4-(5-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804191Notes

Reaction equation

HRID 1804191 reaction equation
[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:18]=[CH:17][C:13]([C:14]([OH:16])=O)=[CH:12][CH:11]=1)([CH3:3])[CH3:2].[CH3:19][C:20]1[CH:21]=[CH:22][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:24][CH:25]=1>>[CH:1]([C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:11]=[CH:12][C:13]([C:14]([N:29]2[CH2:30][CH2:31][N:26]([C:23]3[CH:22]=[CH:21][C:20]([CH3:19])=[CH:25][N:24]=3)[CH2:27][CH2:28]2)=[O:16])=[CH:17][CH:18]=1)([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 114807791-(5-Methyl-2-pyridinyl)piperazineHCID 58484694(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid

Product 1

HCID 67381043(R)-4-isopropyl-3-{4-[4-(5-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 32.1%

Procedure

By reaction and treatment in the same manner as in Example 29 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (374 mg) described in Preparation Example 18 and 1-(5-methylpyridin-2-yl)piperazine (250 mg), the title compound (185 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 29

Sources & evidence

ORD record
ord-6631a4dfe4f94882b64cb09c5892d12e
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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