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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804191Generated: October 31, 2026

1-(5-Methyl-2-pyridinyl)piperazine → (R)-4-isopropyl-3-{4-[4-(5-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804191

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(5-Methyl-2-pyridinyl)piperazineHCID 11480779—
Reactant(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acidHCID 58484694—
Product(R)-4-isopropyl-3-{4-[4-(5-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneHCID 6738104332.1%

Reaction Steps

By reaction and treatment in the same manner as in Example 29 and using (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (374 mg) described in Preparation Example 18 and 1-(5-methylpyridin-2-yl)piperazine (250 mg), the title compound (185 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-6631a4dfe4f94882b64cb09c5892d12e
Source noteuspto-grants-2013_01