(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	(R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid	HCID 58484694	—
Reactant	1-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride	HCID 67381091	—
Product	(R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-isopropyloxazolidin-2-one	HCID 67380778	42.5%

Reaction Steps

By reaction and treatment in the same manner as in Example 29 and using 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine hydrochloride (381 mg) described in Preparation Example 49 and (R)-4-(4-isopropyl-2-oxooxazolidin-3-yl)benzoic acid (374 mg) described in Preparation Example 18, the title compound (286 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-55c3636361f740d28556b1608087f7ba
Source note	uspto-grants-2013_01