HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-ethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid | HCID 58484770 | — |
| Reactant | 1-(3,5-Dimethylpyridin-2-yl)piperazine hydrochloride | HCID 67381379 | — |
| Product | (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-ethyloxazolidin-2-one | HCID 67381186 | 38.2% |
Reaction Steps
By reaction and treatment in the same manner as in Example 49 and using (R)-4-(4-ethyl-2-oxooxazolidin-3-yl)benzoic acid (470 mg) described in Preparation Example 78 and 1-(3,5-dimethylpyridin-2-yl)piperazine hydrochloride (455 mg) described in Preparation Example 64, the title compound (312 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-6a092a07f60540d8b2d45e8a32ae309e |
| Source note | uspto-grants-2013_01 |