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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804203Generated: October 25, 2026

(4R)-4-ethyl-1,3-oxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4-ethyloxazolidin-2-one

https://huagongshe.com/reaction/1804203

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 641503—
Reactant(4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484505—
Product(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4-ethyloxazolidin-2-oneHCID 6738091542.4%

Reaction Steps

By reaction and treatment in the same manner as in Example 1 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (874 mg) described in Preparation Example 61 and (R)-4-ethyloxazolidin-2-one (300 mg) described in Preparation Example 26, the title compound (399 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-7a3ae18a5f1541f88b97de9d62f2023c
Source noteuspto-grants-2013_01