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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804224Generated: November 2, 2026

(R)-2-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methoxyphenyl}-4-methyloxazolidin-2-one hydrochloride

https://huagongshe.com/reaction/1804224

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(R)-2-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acidHCID 58484787—
Reactant1-(3,5-Dimethylpyridin-2-yl)piperazine hydrochlorideHCID 67381379—
Product(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methoxyphenyl}-4-methyloxazolidin-2-one hydrochlorideHCID 6738113437.8%

Reaction Steps

By reaction and treatment in the same manner as in Example 87 and using (R)-2-methoxy-4-(4-methyl-2-oxooxazolidin-3-yl)benzoic acid (1.1 g) described in Preparation Example 45 and 1-(3,5-dimethylpyridin-2-yl)piperazine hydrochloride (956 mg) described in Preparation Example 64, the title compound (731 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-5121c145ef64449aa36863d5d889b4ac
Source noteuspto-grants-2013_01