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HRID1804227

反应详情

EQUATION

反应方程式

HRID 1804227 的结构方程式

REACTANTS

反应物

2
结构：CC[C@@H]1COC(=O)N1
HCID641503

(4R)-4-ethyl-1,3-oxazolidin-2-one

C5H9NO2

结构：Cc1cnc(N2CCN(C(=O)c3ccc(Br)c(F)c3)CC2)c(C)c1
HCID58484572

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@H]1COC(=O)N1c1ccc(C(=O)N2CCN(c3ncc(C)cc3C)CC2)cc1F
HCID67380895

未命名化合物

收率 57.7%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (392 mg) described in Preparation Example 66 and (R)-4-ethyloxazolidin-2-one (138 mg) described in Preparation Example 26, the title compound (246 mg) was obtained.

WORKUP

后处理

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 26