Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804227Generated: October 25, 2026

(4R)-4-ethyl-1,3-oxazolidin-2-one → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-ethyloxazolidin-2-one

https://huagongshe.com/reaction/1804227

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4R)-4-ethyl-1,3-oxazolidin-2-oneHCID 641503—
Reactant(4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484572—
Product(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-4-ethyloxazolidin-2-oneHCID 6738089557.7%

Reaction Steps

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (392 mg) described in Preparation Example 66 and (R)-4-ethyloxazolidin-2-one (138 mg) described in Preparation Example 26, the title compound (246 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-1d2125716a6d4273a4da3bdb06ad941d
Source noteuspto-grants-2013_01