HRID1804237

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID141315

2-Oxazolidinone, 4,4-dimethyl-

C5H9NO2

反应SMILES：CS(=O)(=O)c1cc(Br)ccc1C(=O)N1CCN(c2ncc(C3CC3)cc2C2CC2)CC1

HCID58484601

未命名化合物

PRODUCTS

产物

反应SMILES：CC1(C)COC(=O)N1c1ccc(C(=O)N2CCN(c3ncc(C4CC4)cc3C3CC3)CC2)c(S(C)(=O)=O)c1

HCID67380880

未命名化合物

收率 17.3%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 111 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (463 mg) described in Preparation Example 89 and 4,4-dimethyloxazolidin-2-one (106 mg), the title compound (85.6 mg) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner as in Example 111

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-37c04e63363e4cce889e0ce3c19f40de
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08354401B2
来源说明: uspto-grants-2013_01

反应SMILES

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH:22]4[CH2:24][CH2:23]4)=[CH:20][C:19]([CH:25]4[CH2:27][CH2:26]4)=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[C:4]([S:28]([CH3:31])(=[O:30])=[O:29])[CH:3]=1.[CH3:32][C:33]1([CH3:39])[CH2:37][O:36][C:35](=[O:38])[NH:34]1>>[CH:22]1([C:21]2[C:16]([N:13]3[CH2:14][CH2:15][N:10]([C:8]([C:5]4[CH:6]=[CH:7][C:2]([N:34]5[C:33]([CH3:39])([CH3:32])[CH2:37][O:36][C:35]5=[O:38])=[CH:3][C:4]=4[S:28]([CH3:31])(=[O:30])=[O:29])=[O:9])[CH2:11][CH2:12]3)=[N:17][CH:18]=[C:19]([CH:25]3[CH2:27][CH2:26]3)[CH:20]=2)[CH2:24][CH2:23]1