HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethyl-1,3-oxazolidin-2-one → 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4,4-dimethyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethyl-1,3-oxazolidin-2-one | HCID 141315 | — |
| Reactant | (4-Bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone | HCID 58484601 | — |
| Product | 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-4,4-dimethyloxazolidin-2-one | HCID 67380880 | 17.3% |
Reaction Steps
By reaction and treatment in the same manner as in Example 111 and using (4-bromo-2-methanesulfonylphenyl)[4-(3,5-dicyclopropylpyridin-2-yl)piperazin-1-yl]methanone (463 mg) described in Preparation Example 89 and 4,4-dimethyloxazolidin-2-one (106 mg), the title compound (85.6 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-37c04e63363e4cce889e0ce3c19f40de |
| Source note | uspto-grants-2013_01 |