HRID1804273

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58484701

未命名化合物

结构：COC(=O)c1ccc(N2CCOC2=O)cc1N1CCCS1(=O)=O

HCID58484747

未命名化合物

PRODUCTS

生成物

结构：O=C(c1ccc(N2CCOC2=O)cc1N1CCCS1(=O)=O)N1CCN(c2ncc(C3CC3)cc2C2CC2)CC1

HCID58484812

未命名化合物

收率 22.2%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 63 and using methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate (170 mg) described in Preparation Example 117 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (121 mg) described in Preparation Example 62, the title compound (61 mg) was obtained.

WORKUP

后处理

customBy reaction and treatment in the same manner as in Example 63
customdescribed in Preparation Example 62

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-27643250c10a4707bbcdb9e1a1402508
来源数据集: uspto-grants-2013_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08354401B2
来源说明: uspto-grants-2013_01

反应 SMILES

[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[C:15]([N:17]2[CH2:21][CH2:20][O:19][C:18]2=[O:22])[CH:14]=[CH:13][C:8]=1[C:9]([O:11]C)=O.[CH:24]1([C:27]2[C:28]([N:36]3[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]3)=[N:29][CH:30]=[C:31]([CH:33]3[CH2:35][CH2:34]3)[CH:32]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[C:28]([N:36]3[CH2:37][CH2:38][N:39]([C:9]([C:8]4[CH:13]=[CH:14][C:15]([N:17]5[CH2:21][CH2:20][O:19][C:18]5=[O:22])=[CH:16][C:7]=4[N:3]4[CH2:4][CH2:5][CH2:6][S:2]4(=[O:1])=[O:23])=[O:11])[CH2:40][CH2:41]3)=[N:29][CH:30]=[C:31]([CH:33]3[CH2:35][CH2:34]3)[CH:32]=2)[CH2:25][CH2:26]1