HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,5-Dicyclopropylpyridin-2-yl)piperazine → 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,5-Dicyclopropylpyridin-2-yl)piperazine | HCID 58484701 | — |
| Reactant | Methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate | HCID 58484747 | — |
| Product | 3-{4-[4-(3,5-Dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxoisothiazolidin-2-yl)phenyl}oxazolidin-2-one | HCID 58484812 | 22.2% |
Reaction Steps
By reaction and treatment in the same manner as in Example 63 and using methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate (170 mg) described in Preparation Example 117 and 1-(3,5-dicyclopropylpyridin-2-yl)piperazine (121 mg) described in Preparation Example 62, the title compound (61 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-27643250c10a4707bbcdb9e1a1402508 |
| Source note | uspto-grants-2013_01 |