Methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate → 3-{3-(1,1-Dioxoisothiazolidin-2-yl)-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

HRID 1804274Notes

Reaction equation

HRID 1804274 reaction equation
[O:1]=[S:2]1(=[O:23])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[C:15]([N:17]2[CH2:21][CH2:20][O:19][C:18]2=[O:22])[CH:14]=[CH:13][C:8]=1[C:9]([O:11]C)=O.[CH3:24][C:25]1[C:26]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[N:27][C:28]([CH3:32])=[C:29]([CH3:31])[CH:30]=1>>[O:23]=[S:2]1(=[O:1])[CH2:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:16]=[C:15]([N:17]2[CH2:21][CH2:20][O:19][C:18]2=[O:22])[CH:14]=[CH:13][C:8]=1[C:9]([N:36]1[CH2:37][CH2:38][N:33]([C:26]2[C:25]([CH3:24])=[CH:30][C:29]([CH3:31])=[C:28]([CH3:32])[N:27]=2)[CH2:34][CH2:35]1)=[O:11]

Participants

3

Reactant 2

HCID 58484747Methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoateHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

Product 1

HCID 584846323-{3-(1,1-Dioxoisothiazolidin-2-yl)-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneYield 25%

Procedure

By reaction and treatment in the same manner as in Example 63 and using methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate (170 mg) described in Preparation Example 117 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (103 mg) described in Preparation Example 175, the title compound (64.2 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 63
  2. customdescribed in Preparation Example 175

Sources & evidence

ORD record
ord-b15ee2d5de514b0eb0591d782bda9e52
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

Loading…