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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804274Generated: October 25, 2026

Methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate → 3-{3-(1,1-Dioxoisothiazolidin-2-yl)-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804274

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoateHCID 58484747—
Reactant1-(3,5,6-Trimethylpyridin-2-yl)piperazineHCID 58484823—
Product3-{3-(1,1-Dioxoisothiazolidin-2-yl)-4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}oxazolidin-2-oneHCID 5848463225%

Reaction Steps

By reaction and treatment in the same manner as in Example 63 and using methyl 2-(1,1-dioxoisothiazolidin-2-yl)-4-(2-oxooxazolidin-3-yl)benzoate (170 mg) described in Preparation Example 117 and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (103 mg) described in Preparation Example 175, the title compound (64.2 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-b15ee2d5de514b0eb0591d782bda9e52
Source noteuspto-grants-2013_01