2-Oxazolidinone → (R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-(3-methyl-1,1-dioxoisothiazolidin-2-yl)phenyl}oxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	2-Oxazolidinone	HCID 73949	—
Reactant	(R)-[4-chloro-2-(3-methyl-1,1-dioxoisothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone	HCID 58484709	—
Product	(R)-3-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-(3-methyl-1,1-dioxoisothiazolidin-2-yl)phenyl}oxazolidin-2-one	HCID 58484744	15.1%

Reaction Steps

By reaction and treatment in the same manner as in Example 201 and using (R)-[4-chloro-2-(3-methyl-1,1-dioxoisothiazolidin-2-yl)phenyl][4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (95.1 mg) described in Preparation Example 125 and oxazolidin-2-one (17.9 mg), the title compound (15.9 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-fdac3813ee6b43f6becd350a30276246
Source note	uspto-grants-2013_01