HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Oxazolidinone → 3-{4-[4-(5-Cyano-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Oxazolidinone | HCID 73949 | — |
| Reactant | 6-[4-(4-Bromo-2-fluorobenzoyl)piperazin-1-yl]-5-methylnicotinonitrile | HCID 58484606 | — |
| Product | 3-{4-[4-(5-Cyano-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}oxazolidin-2-one | HCID 58484754 | 81.5% |
Reaction Steps
By reaction and treatment in the same manner as in Example 1 and using 6-[4-(4-bromo-2-fluorobenzoyl)piperazin-1-yl]-5-methylnicotinonitrile (215 mg) described in Preparation Example 134 and oxazolidin-2-one (70 mg), the title compound (178 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-c9099c53f2b546a7b4c61c2a6cc4a5b1 |
| Source note | uspto-grants-2013_01 |