5,5-Dimethyloxazolin-2-one → 3-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one

Participants

Role	Name	HCID	Charge
Reactant	5,5-Dimethyloxazolin-2-one	HCID 21464782	—
Reactant	[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone	HCID 58484841	—
Product	3-{4-[4-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-5,5-dimethyloxazolidin-2-one	HCID 58484625	28.3%

Reaction Steps

By reaction and treatment in the same manner as in Example 110 and using [4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone (447 mg) described in Preparation Example 97 and 5,5-dimethyloxazolin-2-one (138 mg) described in Preparation Example 43, the title compound (123 mg) was obtained.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08354401B2
Source dataset	uspto-grants-2013_01
ORD ID	ord-9660a0a86d294f7da4541a85ad1299f9
Source note	uspto-grants-2013_01