2-Oxazolidinone, 5,5-dimethyl- → HCID 58484639, compound

HRID 1804343Notes

Reaction equation

HRID 1804343 reaction equation
I[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[CH3:25][C:26]1([CH3:32])[O:30][C:29](=[O:31])[NH:28][CH2:27]1>>[CH3:25][C:26]1([CH3:32])[O:30][C:29](=[O:31])[N:28]([C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:15][CH2:14][N:13]([C:16]4[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[C:18]([CH3:24])[N:17]=4)[CH2:12][CH2:11]3)=[O:9])=[CH:4][CH:3]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 1368922-Oxazolidinone, 5,5-dimethyl-HCID 58484793(4-Iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 58484639HCID 58484639, compoundYield 25.5%

Procedure

By reaction and treatment in the same manner as in Example 110 and using (4-iodophenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone (579 mg) described in Preparation Example 176 and 5,5-dimethyloxazolidin-2-one (153 mg) described in Preparation Example 43, the title compound (143 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 110
  2. customdescribed in Preparation Example 43

Sources & evidence

ORD record
ord-7ae8c3e202c647bd961cb5e96e2f0568
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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