2,3,5,6-Tetrachloropyridine → HCID 58484556, compound

HRID 1804345Notes

Reaction equation

HRID 1804345 reaction equation
[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)=[O:17])=[CH:12][CH:11]=1.[Cl:24][C:25]1[C:30]([Cl:31])=[CH:29][C:28]([Cl:32])=[C:27](Cl)[N:26]=1>>[CH3:1][O:2][CH2:3][C@@H:4]1[CH2:8][O:7][C:6](=[O:9])[N:5]1[C:10]1[CH:15]=[CH:14][C:13]([C:16]([N:18]2[CH2:19][CH2:20][N:21]([C:27]3[C:28]([Cl:32])=[CH:29][C:30]([Cl:31])=[C:25]([Cl:24])[N:26]=3)[CH2:22][CH2:23]2)=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 169902,3,5,6-TetrachloropyridineHCID 58484555(R)-4-methoxymethyl-3-[4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one

Product 1

HCID 58484556HCID 58484556, compoundYield 82.2%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-4-methoxymethyl-3-[4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one (972 mg) described in Preparation Example 165 and 2,3,5,6-tetrachloropyridine (990 mg), the title compound (1.25 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-4548ad9a597f4d519abea4dbc5acc91d
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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