2,3,5,6-Tetrachloropyridine → HCID 58484745, compound

HRID 1804347Notes

Reaction equation

HRID 1804347 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:16]2[C@H:20]([CH2:21][O:22][CH3:23])[CH2:19][O:18][C:17]2=[O:24])[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)=[O:9].[Cl:25][C:26]1[C:31]([Cl:32])=[CH:30][C:29]([Cl:33])=[C:28](Cl)[N:27]=1>>[F:1][C:2]1[CH:3]=[C:4]([N:16]2[C@H:20]([CH2:21][O:22][CH3:23])[CH2:19][O:18][C:17]2=[O:24])[CH:5]=[CH:6][C:7]=1[C:8]([N:10]1[CH2:15][CH2:14][N:13]([C:28]2[C:29]([Cl:33])=[CH:30][C:31]([Cl:32])=[C:26]([Cl:25])[N:27]=2)[CH2:12][CH2:11]1)=[O:9]

Participants

3

Reactant 2

HCID 169902,3,5,6-TetrachloropyridineHCID 58484850HCID 58484850, compound

Product 1

HCID 58484745HCID 58484745, compoundYield 72.7%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-3-[3-fluoro-4-(piperazine-1-carbonyl)phenyl]-4-methoxymethyloxazolidin-2-one (405 mg) described in Preparation Example 158 and 2,3,5,6-tetrachloropyridine (390 mg), the title compound (452 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-2b1361004f0c44a2a878adb314ada509
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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