2,3,5,6-Tetrachloropyridine → HCID 58484700, compound

HRID 1804348Notes

Reaction equation

HRID 1804348 reaction equation
[CH2:1]([O:3][CH2:4][C@@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])=[CH:13][CH:12]=1)[CH3:2].[Cl:25][C:26]1[C:31]([Cl:32])=[CH:30][C:29]([Cl:33])=[C:28](Cl)[N:27]=1>>[CH2:1]([O:3][CH2:4][C@@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:20][CH2:21][N:22]([C:28]3[C:29]([Cl:33])=[CH:30][C:31]([Cl:32])=[C:26]([Cl:25])[N:27]=3)[CH2:23][CH2:24]2)=[O:18])=[CH:13][CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 169902,3,5,6-TetrachloropyridineHCID 58484504HCID 58484504, compound

Product 1

HCID 58484700HCID 58484700, compoundYield 84.5%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-4-ethoxymethyl-3-[4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one (500 mg) described in Preparation Example 167 and 2,3,5,6-tetrachloropyridine (488 mg), the title compound (651 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-61f3b2ae8b114e0bbb40edd44d6f74df
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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