2,3,5,6-Tetrachloropyridine → HCID 58484609, compound

HRID 1804350Notes

Reaction equation

HRID 1804350 reaction equation
[CH2:1]([O:3][CH2:4][C@@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[O:18])=[C:13]([F:25])[CH:12]=1)[CH3:2].[Cl:26][C:27]1[C:32]([Cl:33])=[CH:31][C:30]([Cl:34])=[C:29](Cl)[N:28]=1>>[CH2:1]([O:3][CH2:4][C@@H:5]1[CH2:9][O:8][C:7](=[O:10])[N:6]1[C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:24][CH2:23][N:22]([C:29]3[C:30]([Cl:34])=[CH:31][C:32]([Cl:33])=[C:27]([Cl:26])[N:28]=3)[CH2:21][CH2:20]2)=[O:18])=[C:13]([F:25])[CH:12]=1)[CH3:2]

Participants

3

Reactant 2

HCID 169902,3,5,6-TetrachloropyridineHCID 58484589HCID 58484589, compound

Product 1

HCID 58484609HCID 58484609, compoundYield 84.5%

Procedure

By reaction and treatment in the same manner as in Example 147 and using (R)-4-ethoxymethyl-3-[3-fluoro-4-(piperazine-1-carbonyl)phenyl]oxazolidin-2-one (387 mg) described in Preparation Example 160 and 2,3,5,6-tetrachloropyridine (358 mg), the title compound (495 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner as in Example 147

Sources & evidence

ORD record
ord-1cebd12b076a4956b2a05fe3683e78b8
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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