2-Bromoethyl methyl ether → HCID 58484678, compound

HRID 1804353Notes

Reaction equation

HRID 1804353 reaction equation
[OH:1][CH2:2][C@@H:3]1[CH2:7][O:6][C:5](=[O:8])[N:4]1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:19][CH2:18]2)=[O:16])=[CH:11][CH:10]=1.Br[CH2:33][CH2:34][O:35][CH3:36]>>[CH3:36][O:35][CH2:34][CH2:33][O:1][CH2:2][C@@H:3]1[CH2:7][O:6][C:5](=[O:8])[N:4]1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([N:17]2[CH2:18][CH2:19][N:20]([C:23]3[C:28]([CH3:29])=[CH:27][C:26]([CH3:30])=[C:25]([CH3:31])[N:24]=3)[CH2:21][CH2:22]2)=[O:16])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 58484872HCID 58484872, compound

Product 1

HCID 58484678HCID 58484678, compoundYield 37.1%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-4-hydroxymethyl-3-{4-[4-(3,5,6-trimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-oxazolidin-2-one (424 mg) described in Example 294 and 1-bromo-2-methoxyethane (167 mg), the title compound (179 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-ae2cf836686b4dd5b343471c9ff57e22
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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