2-Bromoethyl methyl ether → HCID 58484596, compound

HRID 1804356Notes

Reaction equation

HRID 1804356 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:32])[C:7]([N:10]3[CH2:15][CH2:14][N:13]([C:16]([C:18]4[CH:23]=[CH:22][C:21]([N:24]5[C@H:28]([CH2:29][OH:30])[CH2:27][O:26][C:25]5=[O:31])=[CH:20][CH:19]=4)=[O:17])[CH2:12][CH2:11]3)=[N:8][CH:9]=2)[CH2:3][CH2:2]1.Br[CH2:34][CH2:35][O:36][CH3:37]>>[CH:1]1([C:4]2[CH:5]=[C:6]([CH3:32])[C:7]([N:10]3[CH2:11][CH2:12][N:13]([C:16]([C:18]4[CH:19]=[CH:20][C:21]([N:24]5[C@H:28]([CH2:29][O:30][CH2:34][CH2:35][O:36][CH3:37])[CH2:27][O:26][C:25]5=[O:31])=[CH:22][CH:23]=4)=[O:17])[CH2:14][CH2:15]3)=[N:8][CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 58484731HCID 58484731, compound

Product 1

HCID 58484596HCID 58484596, compoundYield 43.5%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-hydroxymethyloxazolidin-2-one (655 mg) described in Example 299 and 1-bromo-2-methoxyethane (250 mg), the title compound (323 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-65ad96a4ea2a4733927cc06752ba1a6a
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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