2-Bromoethyl methyl ether → HCID 58484629, compound

HRID 1804357Notes

Reaction equation

HRID 1804357 reaction equation
[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:27]5[C@H:31]([CH2:32][OH:33])[CH2:30][O:29][C:28]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:3][CH2:2]1.Br[CH2:36][CH2:37][O:38][CH3:39]>>[CH:1]1([C:4]2[C:5]([N:13]3[CH2:18][CH2:17][N:16]([C:19]([C:21]4[CH:26]=[CH:25][C:24]([N:27]5[C@H:31]([CH2:32][O:33][CH2:36][CH2:37][O:38][CH3:39])[CH2:30][O:29][C:28]5=[O:34])=[CH:23][CH:22]=4)=[O:20])[CH2:15][CH2:14]3)=[N:6][CH:7]=[C:8]([CH:10]3[CH2:12][CH2:11]3)[CH:9]=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 58484854HCID 58484854, compound

Product 1

HCID 58484629HCID 58484629, compoundYield 40.7%

Procedure

By reaction and treatment in the same manner as in Preparation Example 93 and using (R)-3-{4-[4-(3,5-dicyclopropylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-hydroxymethyloxazolidin-2-one (694 mg) described in Example 280 and 1-bromo-2-methoxyethane (250 mg), the title compound (318 mg) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 93

Sources & evidence

ORD record
ord-0250b74c8c7748e2b1457e7fb77706e0
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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