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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1804389Generated: October 27, 2026

1,3-Oxazol-2(5H)-one → 3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}oxazolidin-2-one

https://huagongshe.com/reaction/1804389

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Oxazol-2(5H)-oneHCID 14405094—
Reactant(4-Bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanoneHCID 58484657—
Product3-{4-[4-(5-Cyclopropylpyridin-2-yl)piperazine-1-carbonyl]-3-fluorophenyl}oxazolidin-2-oneHCID 5848482074.4%

Reaction Steps

By reaction and treatment in the same manner as in Example 110 and using (4-bromo-2-fluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone (404 mg) described in Preparation Example 188 and oxazolin-2-one (104 mg), the title compound (305 mg) was obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08354401B2
Source datasetuspto-grants-2013_01
ORD IDord-8b7bb8a633d44ed0a625a72f9e60636e
Source noteuspto-grants-2013_01