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HRID1804395

反应详情

EQUATION

反应方程式

HRID 1804395 的结构方程式

REACTANTS

反应物

2
结构：C[C@@H]1COC(=O)N1
HCID2734858

(R)-4-Methyloxazolidin-2-one

C4H7NO2

结构：Cc1cnc(N2CCN(C(=O)c3ccc(Br)cc3C#N)CC2)c(C)c1
HCID58484628

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cnc(N2CCN(C(=O)c3ccc(N4C(=O)OC[C@H]4C)cc3C#N)CC2)c(C)c1
HCID58484638

未命名化合物

收率 77.8%

PROCEDURE

实验过程

By reaction and treatment in the same manner as in Example 149 and using 5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (399 mg) described in Preparation Example 193 and (R)-4-methyloxazolidin-2-one (121 mg) described in Preparation Example 25, the title compound (326 mg) was obtained.

WORKUP

后处理

  1. customBy reaction and treatment in the same manner as in Example 149
  2. customdescribed in Preparation Example 25