HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-4-Methyloxazolidin-2-one → (R)-3-{3-cyano-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-4-Methyloxazolidin-2-one | HCID 2734858 | — |
| Reactant | 5-Bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile | HCID 58484628 | — |
| Product | (R)-3-{3-cyano-4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]phenyl}-4-methyloxazolidin-2-one | HCID 58484638 | 77.8% |
Reaction Steps
By reaction and treatment in the same manner as in Example 149 and using 5-bromo-2-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzonitrile (399 mg) described in Preparation Example 193 and (R)-4-methyloxazolidin-2-one (121 mg) described in Preparation Example 25, the title compound (326 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354401B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-fe3a11eb637b45b383f29d9c3b98b2bb |
| Source note | uspto-grants-2013_01 |