4-Bromo-2-methanesulfonylbenzoic acid → HCID 67381409, compound

HRID 1804413Notes

Reaction equation

HRID 1804413 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][C@H:10]1[CH3:15].[Br:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](O)=[O:22])=[C:19]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:18]=1>>[Br:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([N:12]2[CH2:13][CH2:14][N:9]([C:3]3[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=3[CH3:1])[C@H:10]([CH3:15])[CH2:11]2)=[O:22])=[C:19]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:18]=1

Participants

3

Reactant 2

HCID 27610574-Bromo-2-methanesulfonylbenzoic acidHCID 67381125HCID 67381125, compound

Product 1

HCID 67381409HCID 67381409, compoundYield 73.2%

Procedure

By reaction and treatment in the same manner as in Preparation Example 67 and using (R)-1-(2,4-dimethylphenyl)-2-methylpiperazine (1.2 g) and 4-bromo-2-methanesulfonylbenzoic acid (1.7 g), (4-bromo-2-methanesulfonylphenyl)[(R)-4-(2,4-dimethylphenyl)-3-methylpiperazin-1-yl]methanone (2.0 g) was obtained.

Workup

  1. customBy reaction and treatment in the same manner
  2. customas in Preparation Example 67

Sources & evidence

ORD record
ord-f12f195b3a9644d382482126993eabe5
Source dataset
uspto-grants-2013_01
Patent number
US08354401B2

Reaction notes

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