Hydrochloric Acid → HCID 68851533, compound

HRID 1804544Notes

Reaction equation

HRID 1804544 reaction equation
[O:1]=[C:2]1[NH:6][CH2:5][CH2:4][N:3]1[C:7]1[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=1)[C:10]#[N:11].[ClH:15]>CO.[Pd]>[ClH:15].[NH2:11][CH2:10][C:9]1[CH:8]=[C:7]([N:3]2[CH2:4][CH2:5][NH:6][C:2]2=[O:1])[CH:14]=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 114581363-(2-oxo-imidazolidin-1-yl)-benzonitrile

Product 1

HCID 68851533HCID 68851533, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

40.00 g (210 mmol) 3-(2-oxo-imidazolidin-1-yl)-benzonitrile are suspended in 1500 ml of methanol, 53 ml 37% hydrochloric acid are added. The mixture is hydrogenated for 20 hours at ambient temperature under a pressure of 7 bar with 4.00 g palladium/charcoal. The catalyst is filtered off, the filtrate is concentrated and the precipitate formed is suction filtered, washed with acetone and dried.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. customthe precipitate formed
  4. filtrationfiltered
  5. washwashed with acetone
  6. customdried

Sources & evidence

ORD record
ord-ba3ecb8c38b043f18ed7f5770cc77687
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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