Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate → 2-(5-Ethyloxazol-2-yl)ethylamine

HRID 1804555Notes

Reaction equation

HRID 1804555 reaction equation
[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH:10]C(=O)OCC2C=CC=CC=2)=[N:5][CH:4]=1)[CH3:2]>CO.[Pd]>[CH2:1]([C:3]1[O:7][C:6]([CH2:8][CH2:9][NH2:10])=[N:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 1

HCID 57636953Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate

Product 1

HCID 115428012-(5-Ethyloxazol-2-yl)ethylamine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2.86 g (10.43 mmol) benzyl [2-(5-ethyl-oxazol-2-yl)-ethyl]-carbamate are placed in 130 ml of methanol, 0.910 mg palladium/charcoal 10% are added, then the mixture is hydrogenated for 5 hours at ambient temperature under a pressure of 14 psi. Then the catalyst is suction filtered and the solution is evaporated down.

Workup

  1. filtrationfiltered
  2. customthe solution is evaporated down

Sources & evidence

ORD record
ord-0bb8f8b4496347e4a8a9fb4994d8c8a2
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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