HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate | HCID 57637115 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine | HCID 24254483 | — |
Reaction Steps
4.00 g (15.67 mmol) tert-butyl [2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 20 ml trifluoroacetic acid are stirred in 200 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08354418B2 |
| Source dataset | uspto-grants-2013_01 |
| ORD ID | ord-e0ab4ef7536c4e8c862400cbe78f2ecb |
| Source note | uspto-grants-2013_01 |