Trifluoroacetic acid → 2-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

HRID 1804565Notes

Reaction equation

HRID 1804565 reaction equation
[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:6][N:5]=1)([CH3:3])[CH3:2].FC(F)(F)C(O)=O>ClCCl>[CH:1]([C:4]1[O:8][C:7]([CH2:9][CH2:10][NH2:11])=[N:6][N:5]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57637115Tert-butyl[2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate

Product 1

HCID 242544832-(5-Isopropyl-1,3,4-oxadiazol-2-YL)ethanamine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.00 g (15.67 mmol) tert-butyl [2-(5-isopropyl-[1,3,4]oxadiazol-2-yl)-ethyl]-carbamate and 20 ml trifluoroacetic acid are stirred in 200 ml dichloromethane for 24 hours at ambient temperature. Then the mixture is evaporated down, the residue is made basic and extracted with ethyl acetate. The organic phase is dried and evaporated to dryness.

Workup

  1. customThen the mixture is evaporated down
  2. extractionextracted with ethyl acetate
  3. customThe organic phase is dried
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-e0ab4ef7536c4e8c862400cbe78f2ecb
Source dataset
uspto-grants-2013_01
Patent number
US08354418B2

Reaction notes

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