反应详情

900 mg (3.53 mmol) tert-butyl [2-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-ethyl]-carbamate are placed in 10 ml dichloromethane, 20 ml 1 molar ethereal hydrochloric acid are added. The reaction mixture is stirred for 16 hours at ambient temperature. After the further addition of 10 ml ethereal hydrochloric acid the mixture is stirred for another 72 hours at ambient temperature and 4 hours at 40° C. The suspension is evaporated down. The residue is dissolved in acetone, mixed with diethyl ether and suction filtered.

1. stirringis stirred for another 72 hours at ambient temperature and 4 hours at 40° C
2. customThe suspension is evaporated down
3. dissolutionThe residue is dissolved in acetone
4. additionmixed with diethyl ether and suction
5. filtrationfiltered