Trifluoroacetic acid → HCID 4914503, compound

HRID 1804623Notes

Reaction equation

HRID 1804623 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)=[N:2]1.FC(F)(F)C(O)=O>ClCCl>[O:1]1[CH:5]=[CH:4][C:3]([CH2:6][N:7]2[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)=[N:2]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67971990HCID 67971990, compound

Product 1

HCID 4914503HCID 4914503, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 0.84 g (3.2 mmol) of the title compound from Step B above in 5 mL dichloromethane and 5 mL trifluoroacetic acid was stirred at ambient temperature for 1 h. All volatiles were removed in vacuo and the crude light brown residue was carried forward without purification. LC/MS: m/z (ES) 168.1 (MH)+.

Workup

  1. customAll volatiles were removed in vacuo
  2. customthe crude light brown residue was carried forward without purification

Sources & evidence

ORD record
ord-f138c0612f8046508b98db055d3ebd0c
Source dataset
uspto-grants-2013_01
Patent number
US08354403B2

Reaction notes

Loading…